A new study advances research and published in the journal Proceedings of the National Academy of Sciences took closer to formulate a new class of medicines and vaccines against strain yeast of drug-resistant.
The most common infections that patients acquire hospital care is a yeast infection. Healthy people tend to get a yeast infection called thrush, vaginal or oral cavity. In particular in patients at risk, yeast cells spread through the blood stream throughout the body, causing systemic candidiasis, a deadly half of these patients.
Treatments efficient targeting of yeast cells, especially those hiding in medical equipment. However, some yeast strains have developed resistance to a full anti-yeast, requiring the need for the development of new drugs.
Scientists from Imperial College have discovered a major feature of the human tissue colonization process in which yeast cells identify and attach to human cells. The next step will be to produce and test in the laboratory, experimental drug compounds – small as it interacts with the yeast cells to stop them from early infection process.
Although most healthy women sometimes suffer from thrush or yeast infection the same light, the danger of yeast lethal if not known. They can be a major health concern for vulnerable hospital patients. Department of Life Sciences at Imperial College, one of the lead researchers who conducted this study, expressed concern over the lack of an effective way to deal with acute cases of this yeast infection. ” Our work allows us to understand the details involved and provide important clues for developing new drugs and clinical applications. ”
The lead author of this study, and the members of his team from the Department of Life Sciences and Center for Structural Biology used Nuclear Magnetic Resonance Imaging (NMR) and X – ray. They examined the structure of Als adhesin, a protein found on the surface of Candida albicans yeast cells, to investigate what it was in recognition of the role of human tissue. These proteins specifically help the yeast infection to thrive throughout the human body.